NeriumAD Safety Information

By October 23, 2012Product, What's New

Dennis Knocke, CEO of Nerium Skincare, sent us the below memo to summarize a recently held toxcology meeting, and the discussions about NeriumAD at this meeting. He also included a link to a video of some of the top doctors in this field discussing the safety of NeriumAD at this gathering. This is a must-read memo and must-watch video for all. It is important to be armed with knowledge on this topic so you can easily disarm any misconceptions.

“I just returned from our annual visit to a toxicology meeting in Las Vegas. As usual, we exhibited and shared product safety information and provided NeriumAD Age-Defying Treatment product samples to the attending MD, PhD, Phar.D., FDA, FBI Toxicologist/Pharmacologist and Poison Control Center Directors, etc. We were also able to capture some video on NeriumAD safety, which can be viewed at

I am very excited about how well this year’s meeting went. First, we initiated a new system to provide for feedback from individuals receiving samples. This feedback from several hundred of these healthcare professionals will only add to our safety data. We also received very positive feedback from individuals who had taken samples last year.

Second, and more important, we were able to organize a NeriumAD Safety Panel Presentation/Discussion at the meeting. The panelists included five independent MD, Pediatric MD, PhD, Phar.D., and professors of Pharmacology and Toxicology, one a former Medical Officer for the Food and Drug Administration. Needless to say, it was a very distinguished panel with the ability and credibility to speak to safety; and recognizable individuals to the members of the North American Congress of Clinical Toxicology. The presentation/discussion included the review of Dr. Newman’s research and ST&T clinical data, a review of the data base of the American Association of Poison Control Centers as it relates to Nerium oleander, comments about the confusion associated with the generic term “oleander,” comments about what is credible information on the Internet and myths about Nerium oleander, toxicity of NeriumAD as it relates to children, comparison to other safe products that contain toxic compounds, and the final consensus on the safety of NeriumAD. The conclusion of the panel was that NeriumAD was safe. I will share an overview of the presentations, discussion, and comments of this panel.

Since you are aware of Dr. Newman’s and ST&T’s research, I will start with commentary pertaining to toxic plants, where one panelist (a director from one of the Poison Control Centers, who has studied the National Poison Control Center database of all reports from plant-based poison incidents) commented specifically about Nerium oleander. He shared that the term “oleander” needs to be put in a generic term. There is Nerium oleander (used in NeriumAD), which is often mistaken for a different plant called Thevetia peruviana (referred to as yellow oleander), This yellow-flowered plant is responsible for a large number of toxic reports and is often confused as oleander in a generic sense. So when you hear “Nerium oleander,” you may confuse it with a plant that has a much more poisonous, toxic reputation, when it actually is not poisonous. This toxicologist’s word of advice was to not believe everything you read on the Internet relating to plants, particularly relating to Nerium oleander.

He referenced a number of myths that circulate about Nerium oleander and have been referenced on the Internet. As an example, one myth is that one leaf of Nerium oleander will kill a child. Another is that a group of Boy Scouts roasted hot dogs on Nerium oleander sticks and, as a consequence, all died. He referred to these examples as strictly myths. He shared his research on a rather large database that contains case studies of plant poisonings from the American Association of Poison Control Centers. He shared the unintentional and intentional data and put the data in perspective. In about 2.3 million plant exposures over the last 25 years, there have been only 43 deaths due to plant ingestion in the United States. None of them have involved Nerium oleander, and there are absolutely no fatalities associated.

A summary of the comments of another Pediatric MD at a prominent children’s hospital and Professor of Toxicology and Pharmacology are as follows. The amount of oleander in the entire container of NeriumAD is a non-toxic dose, even to children. He went on to estimate that a one-year-old child could ingest the entire contents of 400 bottles of NeriumAD and it would still remain a non-toxic dose of NeriumAD. In addition, he commented that in all his years of experience, young children do not ingest significant volumes of creams and ointments. He shared that in his 40 years of private practice and experience with his associated Poison Control Center, he is not aware of even one death of a child by ingestion of creams or ointments, as young children are just not wired to ingest large quantities of these types of substances. He proceeded to comment on the NeriumAD container design and shared that the container presented a daunting challenge for the extraction of significant volumes of cream by adults, let alone young children.

Another MD, PhD, Medical Pharmacologist and Toxicologist shared a quote from Paracelsus (1493-1541), who said, “All things are poison and nothing is without poison.” However, “the dose makes the poison.” He noted that humans use and consume daily foods which are known to contain trace amounts of natural carcinogens and toxins (apricots, apples, tea, cocoa, coffee, cherries, black pepper, mushrooms, etc.). The risk is relative and it is “the amount consumed” that matters. He presented some examples of food containing toxins, such as potatoes and tomatoes, which contain Gycoalkaloids and Solenines. In addition, almonds, apricots, and cherries contain Cyanogenic Glycosides, castor beans contain Ricin, puffer fish contain Fugu, rhubarb contains xalates, and mushrooms contain Muscarine.

He also noted that Botox is one of the most toxic chemicals we have, but it has been possible to adjust the dose, allowing it to be used by thousands of individuals. He went on to cover ED50, TD50, LD50, Dose/Response Curve, Therapeutic Index, Margins of Safety, etc. At the end of the day, he commented that, “As a result of the studies, the study design, and data captured, NeriumAD has no evidence of toxicity and no absorption into the systemic circulation.” He concluded that the NeriumAD product is perfectly safe to use.
I should mention that at the end of the presentation, the best part was when one of the attendees stood up and announced that she had been using NeriumAD for a year now and loved it. In closing, this was a great meeting for all of us and I think the video will speak for itself.”



Join the discussion 19 Comments

  • […] In a memo about the NACCT meeting, Nerium Biotechnology’s CEO, Dennis Knocke, shared that a leading MD, Ph.D., medical pharmacologist and toxicologist reported the following regarding the safety of NeriumAD: “As a result of the studies, the study design, and data captured, NeriumAD has no evidence of toxicity and no absorption into the systemic circulation.” Read the full memo from Knocke. […]

  • Isabel Ward says:

    Thank you, Nerium International, for such helpful information. This should take care of all misconceptions about NeriumAD safety!

  • Leslie Carey says:

    We need to put more information out there to protect Nerium…but thank you for this information. It really puts it in propective. My husband is allergic to all kinds of plants and animals…yet he uses NeriumAD every night and has only seen results. Never any redness itching or rised skin…Bravo NeriumAD!

  • I love that Nerium uses REAL science to develop our products! I know we are in great hands with Nerium Biotech and our team!

  • Setria James says:

    Nerium, thanks for providing such rich information regarding the science behind the results.

  • Dana Jackson says:

    Thank you, Nerium, for providing such great information. Now let’s spread the word! This product is amazing!

  • Ninja Mel says:

    Wow ! Very impressed how dedicated Nerium International is to taking the neccessary precautions in making this product safe and non-toxic.

  • Janice R says:

    It’s good to have researchable information on the safety of using a product. Nerium has concluded that NeriumAD is perfectly safe to use. “Real Results, Real Science”

  • Paddy McCracken says:

    Nerium’s Revenue of 100Million in 2012 is a pretty good indication to not only the effectiveness of the product but also the safety!

  • Larry Zimberg says:

    It’s so reassuring that Nerium provides all the tools to help us succeed. The product, science, and safety info is all there for us to just point to instead of having to explain. Thanks Nerium!

  • Daye Proffit says:

    I am glad Nerium knows that documentation beats speculation every time. The professionalism informing Nerium is awesome!!

  • Alain Sears says:

    As a mom always professes, SAFETY 1st… Thanks for clearing this up for everyone Dennis Knocke!!!

  • Hollie S. says:

    NeriumAD safety information at its finest! Pass this along to your Nerium Family!

  • Angela Rogers says:

    It is so great that Nerium will share all of this important information about the product as well as the company to everyone. Which from my stand point shows how REAL NeriumAD is.

  • Angela B says:

    This should take care of all misconceptions about NeriumAD safety! The product, science, and safety info is all there for us to just point to instead of having to explain. Thanks Nerium!

  • Sherry Johnson says:

    Great Nerium safety information!

  • Denise V says:

    Nerium takes every safety precaution regarding its product, and it shares it with everyone!

  • Erica Chang says:

    Nerium has so many resources available regarding the safety of its consumers its crazy.

  • […] Ok, so by now you have probably seen the drastic before and after photos posted by people so excited over their transformation by Nerium, but is it safe to use? Will it work on me? I hate those “sign up and sell” things, is this complicated and what if I don’t want to sell Nerium as a business? I had all these thoughts, too. So here is what I’ve found out… Nerium Oleander is the main ingredient. Here is a link to a video by a leading professor of pharmacology and pediatrics reporting his findings. […]

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